Endocrine Abstracts

Introduction: Dyslipidaemia is a common metabolic derangement in polycystic ovary syndrome (PCOS) and may be represented with different lipid alterations. The aim of this study was to evaluate lipid profile in different PCOS phenotypes.Methods: We evaluated 365 PCOS women (PCOS: 25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (controls: 25.41±5.16 kg/m2; 30.35&...

Introduction: Insulin resistance and obesity are common features of polycystic ovary syndrome (PCOS) and both are independently associated with dysglycaemia. The aim of this study was to determine prevalence of dysglycaemia in obese women with PCOS.Methods: PCOS was diagnosed using ESHRE/ASRM criteria. Obesity was defined as BMI ≥25 kg/m2. We evaluated 100 obese women with PCOS (PCOS group: 28.99±3.05 kg/m2; 27.70±5....

Introduction: Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy among women during reproductive age. PCOS cardinal manifestations include hyperandrogenism, oligo/anovulation, and/or polycystic ovarian morphology, and is closely linked to metabolic disorders such as obesity and insulin resistance (IR). It was observed that single-point insulin sensitivity estimator (SPISE) index is associated with metabolic abnormalities and could predict glucose regulation ...

Introduction: Insulin resistance (IR) is a well recognised feature in women with polycystic ovary syndrome (PCOS). The aim of this study was to analyse IR indices obtained from oral glucose tolerance test (OGTT), in different PCOS phenotypes.Methods: We evaluated 240 PCOS women (PCOS: 24.86±5.97 kg/m2; 25.25±4.98 years) diagnosed using ESHRE/ASRM criteria and 70 BMI-matched healthy women (controls: 26.14±4.86 kg/m2; 3...

Introduction: Although phenotype D is well recognised in clinical studies about PCOS, there is still a debate if this phenotype should be evaluated as part of PCOS spectrum. The aim of this study was to evaluate usual anthropometric characteristics in PCOS phenotypes.Methodology: We evaluated 365 PCOS women (PCOS: 25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (Controls: 25.4...

Obesity is closely associated with PCOS and worsens its metabolic and reproductive characteristics. The aim of this study was to evaluate body composition in different PCOS phenotypes. We evaluated 365 PCOS women (PCOS: 25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (Controls: 25.41±5.16 kg/m2; 30.35±5.62 years). PCOS were analyzed through four phenotypes: a (anovulation (ANOV)...

Introduction: Women with PCOS have increased risk for non-alcoholic fatty liver disease (NAFLD). Alanine aminotransferase (ALT) is a sensitive indicator of liver cell injury. The aim of this study is to determine levels of liver enzymes in normal-weight women with PCOS.Methods: PCOS was diagnosed using ESHRE/ASRM criteria. Normal weight was defined as BMI ≤25 kg/m2. We evaluated 62 normal weight women with PCOS (PCOS group: 20.99±1....

Introduction: Women with polycystic ovary syndrome (PCOS) have higher prevalence of metabolic syndrome (MS) than healthy women. However, it is still unclear weather this is a consequence of PCOS per se or higher prevalence of obesity in this population. The aim of this study was to determine prevalence of MS in obese women with PCOS.Methods: PCOS was diagnosed using ESHRE/ASRM criteria. Obesity was defined as BMI ≥25 kg/m2. We e...

Introduction: It has been shown that most women with polycystic ovary syndrome (PCOS) have increased adrenal androgen production, enhanced peripheral metabolism of cortisol and elevated in urinary excretion of its metabolites. Simultaneously, this increased cortisol clearance in PCOS was shown to be followed by a compensatory overdrive of the hypothalamo–pituitary–adrenal (HPA) axis. The aim of this study was to determine HPA axis sensitivity in women woth PCOS.<...

Introduction: Lipid accumulation product (LAP) has been validated as good surrogate marker for the presence of metabolic syndrome (MetS) in general population. The aim of this study was to evaluate LAP in different PCOS phenotypes and to determine its association with MetS.Methods: We evaluated 365 PCOS women (PCOS: 25.05±6.24−kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (contro...